What is primary biliary cholangitis (PBC)?

Updated: Nov 08, 2017
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
  • Print
Answer

Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is a chronic and progressive cholestatic disease of the liver. The name change reflects the fact that cirrhosis occurs only in the late stage and therefore does not correctly identify patients with early-stage disease. [1] The etiology of this disease is unknown, although it is presumed to be autoimmune in nature. The major pathology of this disease is a destruction of the small-to-medium bile ducts, which leads to progressive cholestasis and often end-stage liver disease.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!