What are the pharmacologic treatment options for primary biliary cholangitis (PBC)?

Updated: Nov 08, 2017
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Pharmacologic treatment of PBC is as follows:

  • Ursodeoxycholic acid (UDCA) is the major medication used to slow the progression of the disease

  • Obeticholic acid may be considered in combination with UDCA in adults with an inadequate response to UDCA for at least 1 year or as monotherapy in adults unable to tolerate UDCA

  • Methotrexate may produce improvement in biochemical and histologic findings

  • Corticosteroids may alleviate symptoms and improve biochemical and histologic findings

  • Cyclosporine has some therapeutic potential

  • Colchicine has been used with limited effect

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