Which physical findings are characteristic of primary biliary cholangitis (PBC)?

Updated: Nov 08, 2017
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Answer

Physical examination findings depend on the stage of the disease. In the early stages, examination findings are normal. As the disease advances, the following signs may be noted:

  • Hepatomegaly (25%)

  • Hyperpigmentation (25%)

  • Splenomegaly (15%)

  • Jaundice (10%)

  • Xanthomas and Xanthelasmas (10%): In late stages of the disease

  • Sicca syndrome (50-75%): Xerophthalmia (ie, dry eyes), xerostomia (ie, dry mouth)

  • Kayser-Fleischer rings (extremely rare)


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