How is hepatocellular adenoma (HCA) classified?

Updated: Feb 21, 2018
  • Author: Bradford A Whitmer, DO; Chief Editor: BS Anand, MD  more...
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Answer

A new, not yet universally accepted, Bordeaux classification of hepatocelluar adenoma is currently being evaluated. This subclassification includes hepatocyte nuclear factor 1α-inactivated HCA (HNF1α HCA 30-35%), β-catenin-mutated HCA (β-cat HCA 10-15%), inflammatory HCA (50%), and a subgroup of less than 10% that remains unclassified. [12]

This classification may be important because the β-catenin mutation appears to be related to hepatocellular carcinoma. [13, 14, 15] A small study suggests that being overweight or obese may cause an increase in inflammatory HCA and β-catenin activated-inflammatory HCA subgroups. [16]

Telangiectatic adenoma is a recently recognized variant of HCA formerly classified as a type of focal nodular hyperplasia. This is in the subcategory of inflammatory hepatocellular adenomas. [12]


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