What is the effect of insulin-like growth factor I (IGF-I) on a women's risk for breast cancer?

Updated: Dec 26, 2019
  • Author: Graham A Colditz, MD, DrPH; Chief Editor: Chandandeep Nagi, MD  more...
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Answer

Answer

Insulin-like growth factor I (IGF-I) is a polypeptide hormone with structural homology to insulin, and it is regulated primarily by growth hormone. There is increasing evidence that the growth hormone-IGF-I axis stimulates proliferation of both breast cancer and normal breast epithelial cells.


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