What is included in the general management for multiple organ dysfunction syndrome (MODS) in sepsis?

Updated: Jan 27, 2020
  • Author: Ali H Al-Khafaji, MD, MPH, FACP, FCCP, FCCM; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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General management is as follows [20] :

  • Protocolized, quantitative resuscitation of patients with sepsis-induced tissue hypoperfusion

  • Goals during the first 6 hours of resuscitation are (1) central venous pressure 8-12 mm Hg, (2) mean arterial pressure (MAP) above 65 mm Hg, (3) urine output above 0.5 mL/kg/h, (4) central venous (superior vena cava) or mixed venous oxygen saturation 70% or 65%, respectively

  • In patients with elevated lactate levels, targeting resuscitation to normalize lactate as rapidly as possible

  • Screening for sepsis and performance improvement

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