What is the role of immunosuppression in the treatment multiple organ dysfunction syndrome (MODS) in sepsis?

Updated: Jan 27, 2020
  • Author: Ali H Al-Khafaji, MD, MPH; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
  • Print
Answer

The pathogenesis of septic shock and MODS derives from mediators produced because of the immune response of the host. Despite encouraging data from animal studies, immunosuppressive agents, such as high-dose corticosteroids, have not shown any benefit in humans.

The Surviving Sepsis Campaign recommends that glucose levels in the septic patient should be kept at less than 150 mg/dL.

Research has focused on modifying the host response to sepsis via a number of approaches, including the following:

  • Antibodies against gram-negative endotoxin

  • Gamma globulins

  • Monoclonal antibodies against tumor necrosis factor

  • Blockade of eicosanoid production

  • Blockade of interleukin (IL)–1 activity

  • Inhibition of nitric oxide (NO) synthase

These approaches have met with modest success in animal experiments, but at present, they cannot be recommended for general use in humans.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!