What is the significance of increased interleukin 6 (IL-6) levels in systemic inflammatory response syndrome (SIRS)?

Updated: May 07, 2018
  • Author: Lewis J Kaplan, MD, FACS, FCCM, FCCP; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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Patients who meet SIRS criteria and have increased interleukin 6 (IL-6) levels (>300 pg/mL) have been shown to be at increased risk for complications such as pneumonia, multiple organ dysfunction syndrome (MODS), and death. [16] In addition, a decrease in IL-6 by the second day of antibiotic treatment has been shown to be a marker of effectiveness of therapy and a positive prognostic sign in those patients with an infectious etiology for their SIRS. [17]

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