What are the noninfectious causes of systemic inflammatory response syndrome (SIRS)?

Updated: May 07, 2018
  • Author: Lewis J Kaplan, MD, FACS, FCCM, FCCP; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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Answer

The following is a partial list of the noninfectious causes of SIRS:

  • Acute mesenteric ischemia

  • Adrenal insufficiency

  • Autoimmune disorders

  • Burns

  • Chemical aspiration

  • Cirrhosis

  • Cutaneous vasculitis

  • Dehydration

  • Drug reaction

  • Electrical injuries

  • Erythema multiforme

  • Hemorrhagic shock

  • Hematologic malignancy

  • Intestinal perforation

  • Medication side effect (eg, from theophylline)

  • Myocardial infarction

  • Pancreatitis [6]

  • Seizure

  • Substance abuse - Stimulants such as cocaine and amphetamines

  • Surgical procedures

  • Toxic epidermal necrolysis

  • Transfusion reactions

  • Upper gastrointestinal bleeding

  • Vasculitis


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