Which medications in the drug class Cholinesterase inhibitors, peripheral are used in the treatment of Snakebite?

Updated: Apr 09, 2021
  • Author: Spencer Greene, MD, MS, FACEP, FACMT, FAAEM; Chief Editor: Joe Alcock, MD, MS  more...
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Answer

Cholinesterase inhibitors, peripheral

Anticholinesterase inhibitors interfere with the degradation of acetylcholine by acetylcholinesterase, thereby increasing the amount of acetylcholine available at the neuromuscular junction and increasing the chance of activating the acetylcholine receptors.

Neostigmine (Bloxiverz, Prostigmin)

Neostigmine is a peripherally acting inhibitor of acetylcholinesterase. It allows acetylcholine concentrations at the neuromuscular junction to rise and overcome any postsynaptic blockade by the alpha-toxins that may be present in coral snake venom.


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