What causes impaired host defense mechanisms which increase the risk of sepsis/septic shock?

Updated: Oct 07, 2020
  • Author: Andre Kalil, MD, MPH; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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Patients with impaired host defense mechanisms are at greatly increased risk for sepsis. The main causes of impaired host defense are as follows:

  • Chemotherapeutic drugs

  • Malignancy

  • Severe trauma

  • Burns

  • Diabetes mellitus

  • Renal or hepatic failure

  • Advanced age

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