How are corticosteroids used in the treatment of ARDS in sepsis/septic shock?

Updated: Oct 07, 2020
  • Author: Andre Kalil, MD, MPH; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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Answer

High-dose corticosteroids, though not useful in early management, can improve survival in patients whose ARDS is not resolving. In a study by Meduri et al, prolonged administration of methylprednisolone in patients with nonresolving ARDS was associated with improvement and reduced mortality. [112] Mortality was 0/16 (0%) for the treatment group and 5/8 (62%) for the placebo group in the ICU. The rate of infections, including pneumonia, was similar in the 2 groups. More evidence is needed regarding steroid use and ARDS.


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