When is high-dose corticosteroid therapy indicated in the treatment of sepsis/septic shock?

Updated: Oct 07, 2020
  • Author: Andre Kalil, MD, MPH; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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High-dose corticosteroids should not be used in patients with sepsis or septic shock. A meta-analysis of prospective, randomized, controlled trials of glucocorticoid use did not find any benefit from corticosteroids and suggested that their use could be harmful. [97] A review of 3 meta-analyses found that use of low-dose corticosteroids did not improve survival in septic shock and sepsis and that they were associated with side effects that included superinfections, bleeding, and hyperglycemia. [98]

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