Which antibiotics are not recommended for treatment of intra-abdominal infections in sepsis/septic shock?

Updated: Oct 07, 2020
  • Author: Andre Kalil, MD, MPH; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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Answer

Antibiotics that are not recommended for treating intra-abdominal infections, because of the greater prevalence of resistance, include ampicillin-sulbactam and quinolones (high resistance in community-acquired E coli), as well as cefotetan and clindamycin (high resistance in Bacteroides fragilis). [2] In addition, aminoglycosides, because of their toxicity and the availability of other agents, are not recommended for routine use in community-acquired abdominal infections.


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