What are the guidelines for antibiotic therapy for non-ICU patients with pneumonia and sepsis/septic shock?

Updated: Oct 07, 2020
  • Author: Andre Kalil, MD, MPH; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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For inpatients with pneumonia who are not admitted to the ICU, the guidelines formulated by the Infectious Diseases Society of America (IDSA) and the American Thoracic Society (ATS) recommend administering the following [66] :

  • A respiratory fluoroquinolone, especially in penicillin-allergic patients

  • A beta-lactam agent (cefotaxime, ceftriaxone, or ampicillin) plus a macrolide; ertapenem may be used for selected patients, and doxycycline may be an alternative to the macrolide

  • Antibiotic therapy for a minimum of 5 days for community-acquired pneumonia; the treatment duration may be increased in complicated cases or in cases where the initial therapy did not provide a clinical response against the identified organism

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