When is combination empiric therapy indicated in the treatment of sepsis/septic shock and for how long?

Updated: Oct 07, 2020
  • Author: Andre Kalil, MD, MPH; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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Combination empiric therapy is recommended for patients with the following [11] :

  • Difficult-to-treat, multidrug-resistant microorganisms (eg, Pseudomonas and Acinetobacter species)

  • Severe infections associated with respiratory failure and septic shock

  • Septic shock and bacteremia from pneumococci

However, combination therapy should be limited to 3-5 days, after which period treatment should switch to the most appropriate monotherapy once the results of the susceptibility profile are available. [11, 60]

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