When is epinephrine used in the treatment of sepsis/septic shock?

Updated: Oct 07, 2020
  • Author: Andre Kalil, MD, MPH; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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Epinephrine can increase MAP by increasing cardiac index and stroke volume, as well as by increasing systemic vascular resistance and heart rate. This agent may increase oxygen delivery and oxygen consumption. The use of epinephrine is recommended only in patients who are unresponsive to traditional agents. The undesirable effects of epinephrine include the following:

  • An increase in systemic and regional lactate concentrations

  • The potential to produce myocardial ischemia and promote development of arrhythmias

  • Reduced splanchnic flow

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