Which receptors are involved in the initiation of sepsis response in sepsis/septic shock?

Updated: Oct 07, 2020
  • Author: Andre Kalil, MD, MPH; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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Answer

The following three families of pattern recognition receptors are involved in the initiation of the sepsis response:

  • Toll-like receptors (TLRs)

  • Nucleotide-oligomerization domain leucine-rich repeat proteins

  • Cytoplasmic caspase activation and recruiting domain helicases

These receptors trigger the innate immune response and modulate the adaptive immune response to infection. [13]


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