Which lab studies are indicated in the workup of sepsis/septic shock?

Updated: Oct 07, 2020
  • Author: Andre Kalil, MD, MPH; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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The following are investigative studies to detect a clinically suspected focal infection, the presence of a clinically occult focal infection, and complications of sepsis and septic shock:

  • Complete blood count with differential

  • Coagulation studies (eg, prothrombin time [PT], activated partial thromboplastin time [aPTT], fibrinogen levels)

  • Blood chemistry (eg, sodium, chloride, magnesium, calcium, phosphate, glucose, lactate)

  • Renal and hepatic function tests (eg, creatinine, blood urea nitrogen, bilirubin, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, albumin, lipase)

  • Blood cultures

  • Urinalysis and urine cultures

  • Gram stain and culture of secretions and tissue

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