Which medications in the drug class Xanthine Derivatives are used in the treatment of Respiratory Failure?

Updated: Apr 07, 2020
  • Author: Ata Murat Kaynar, MD; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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Answer

Xanthine Derivatives

Xanthine derivatives may relax smooth muscle of the bronchi.

Theophylline (Elixophyllin Elixir, Theo-24)

Theophylline has a number of physiologic effects, including increases in collateral ventilation, respiratory muscle function, mucociliary clearance, and central respiratory drive. It partially acts by inhibiting phosphodiesterase, elevating cellular cAMP levels, or antagonizing adenosine receptors in the bronchi, resulting in relaxation of smooth muscle. However, its clinical efficacy is controversial, especially in the acute setting.


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