What are the risks of mechanical ventilation in patients with obstructive airway disease-related respiratory failure?

Updated: Apr 07, 2020
  • Author: Ata Murat Kaynar, MD; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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Answer

In patients with chronic obstructive pulmonary disease (COPD) or asthma, initiation of mechanical ventilation may worsen dynamic hyperinflation (auto-PEEP or intrinsic PEEP [PEEPi]). The dangers of auto-PEEP include reduction in cardiac output and hypotension (because of decreased venous return), as well as barotrauma.


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