Which medications in the drug class Antidotes, OP poisoning are used in the treatment of Organophosphate Toxicity?

Updated: Dec 31, 2020
  • Author: Kenneth D Katz, MD, FAAEM, ABMT; Chief Editor: Sage W Wiener, MD  more...
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Antidotes, OP poisoning

These agents prevent aging of AChE and reverse muscle paralysis with OP poisoning.

Pralidoxime (2-PAM, Protopam)

Nucleophilic agent that reactivates the phosphorylated AChE by binding to the OP molecule. Used as an antidote to reverse muscle paralysis resulting from OP AChE pesticide poisoning but is not effective once the OP compound has aged. Current recommendation is administration within 48 h of OP poisoning. Because it does not significantly relieve depression of the respiratory center or decrease muscarinic effects of AChE poisoning, administer atropine concomitantly to block these effects of OP poisoning.

Signs of atropinization might occur earlier with addition of 2-PAM to treatment regimen.

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