Which agents are being investigated for the treatment of organophosphate (OP) toxicity?

Updated: Dec 31, 2020
  • Author: Kenneth D Katz, MD, FAAEM, ABMT; Chief Editor: Sage W Wiener, MD  more...
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Possible future interventions include neuroprotective agents used to prevent nerve damage and bioscavengers aimed to prevent AChE inhibition by nerve agents or OP. Investigations into adjunctive and alternative therapies have mostly used animal models and have resulted in variable conclusions. [26, 27, 28]  In a study of rats poisoned with sarin, Lewine et al reported that the addition of ketamine to standard countermeasures (atropine, 2-PAM, and midazolam) provides clinically relevant additional protection against the negative neurobiological consequences of sarin, even when initiation of treatment is delayed by almost an hour. [28]  

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