Which combination therapy is used to treat organophosphate (OP) toxicity?

Updated: Sep 22, 2018
  • Author: Kenneth D Katz, MD, FAAEM, ABMT; Chief Editor: Sage W Wiener, MD  more...
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Answer

A single-center, randomized, single-blind study by Pajoumand et al found a benefit to magnesium therapy in addition to standard oxime and atropine therapy in reducing hospitalization days and mortality rate in patients with OP poisoning. [24] The mechanisms appear to be inhibition of acetylcholine (ACh) and OP antagonism. A phase II study of magnesium therapy in 50 patients with acute OP poisoning reported no adverse reactions. [25] Larger randomized studies are needed to demonstrate the efficacy of magnesium in this setting.


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