How is organophosphate (OP) toxicity diagnosed?

Updated: Sep 22, 2018
  • Author: Kenneth D Katz, MD, FAAEM, ABMT; Chief Editor: Sage W Wiener, MD  more...
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Answer

Organophosphate (OP) toxicity is a clinical diagnosis. Confirmation of organophosphate poisoning is based on the measurement of cholinesterase activity; typically, these results are not readily available in a clinically relevant timeframe. Although red blood cell (RBC) and plasma (pseudo) cholinesterase (PChE) levels can both be used, RBC cholinesterase correlates better with central nervous system (CNS) acetylcholinesterase (AChE) and is, therefore, a more useful marker of organophosphate poisoning.


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