What are the clinical presentations of organophosphate (OP) toxicity in children and adults?

Updated: Sep 22, 2018
  • Author: Kenneth D Katz, MD, FAAEM, ABMT; Chief Editor: Sage W Wiener, MD  more...
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Answer

Clinical presentation may vary, depending on the specific agent, exposure route, and amount. Signs and symptoms are due to both muscarinic and nicotinic effects.

Interestingly, a review of 31 children with organophosphate (OP) poisoning described that, in contrast to adults, the most common presentations were seizure and coma with relatively less muscarinic or nicotinic findings. [10] The authors hypothesized that the difference may be due to difficulty in detecting muscarinic findings in infants (eg, crying) and ingestion of contaminated produce instead of direct exposure to organophosphates.


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