What is the prophylaxis regimen for endocarditis in patients allergic to penicillin and unable to take oral medication?

Updated: Feb 05, 2018
  • Author: Mary L Windle, PharmD; Chief Editor: Karlheinz Peter, MD, PhD  more...
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Answer

Answer

Clindamycin

Adult dose: 600 mg IV

Pediatric dose: 20 mg/kg IV; not to exceed 600 mg/dose

Cefazolin or ceftriaxone (do not use cephalosporins in patients with a history of immediate-type hypersensitivity penicillin allergy, such as urticaria, angioedema, anaphylaxis)

Adult dose: 1 g IV/IM

Pediatric dose: 50 mg/kg IV/IM; not to exceed 1 g/dose


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