Which antibiotics are used in prophylactic regimens for endocarditis?

Updated: Feb 05, 2018
  • Author: Mary L Windle, PharmD; Chief Editor: Karlheinz Peter, MD, PhD  more...
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Answer

Answer

The most common cause of endocarditis for dental, oral, respiratory tract, or esophageal procedures is S viridans (alpha-hemolytic streptococci). Antibiotic regimens for endocarditis prophylaxis are directed toward S viridans, and the recommended standard prophylactic regimen is a single dose of oral amoxicillin. Amoxicillin, ampicillin, and penicillin V are equally effective in vitro against alpha-hemolytic streptococci; however, amoxicillin is preferred because of superior gastrointestinal absorption that provides higher and more sustained serum levels.

All doses shown below are administered once as a single dose 30-60 min before the procedure.


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