In which cardiac conditions is prophylactic regimens for endocarditis indicated?

Updated: Feb 05, 2018
  • Author: Mary L Windle, PharmD; Chief Editor: Karlheinz Peter, MD, PhD  more...
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Antibiotic prophylaxis is indicated for the following high-risk cardiac conditions:

  • Prosthetic cardiac valve 
  • History of infective endocarditis (see image below) 
  • Congenital heart disease (CHD) (except for the conditions listed, antibiotic prophylaxis is no longer recommended for any other form of CHD): (1) unrepaired cyanotic CHD, including palliative shunts and conduits; (2) completely repaired congenital heart defect with prosthetic material or device, whether placed by surgery or by catheter intervention, during the first 6 months after the procedure; and (3) repaired CHD with residual defects at the site or adjacent to the site of a prosthetic patch or prosthetic device (which inhibits endothelialization) 
  • Cardiac transplantation recipients with cardiac valvular disease

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