How are ER and PgR testing results interpreted in breast tumors?

Updated: Mar 20, 2019
  • Author: Oudai Hassan, MD; Chief Editor: Chandandeep Nagi, MD  more...
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Interpretation and reporting

The percentage or proportion of cells expressing the antigen should be specified in the pathology report. [7] ER and PgR are nuclear stains. When clinicians decide to use hormonal therapy, any ER staining is considered relevant. At some low levels of expression, there is minimal or absent benefit of administration of endocrine therapy.

Scoring systems that incorporate both intensity of staining and the proportion of cells that stain, such as the Allred score, have been correlated with response to therapy. [8]  However, there is currently no generally accepted scoring system. The pathologist plays an important role in avoiding false-negative results (see below).

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