When should HER2 and ER testing of core biopsy and excision breast specimens be performed?

Updated: Mar 20, 2019
  • Author: Oudai Hassan, MD; Chief Editor: Chandandeep Nagi, MD  more...
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Answer

Answer

Excellent concordance for human epidermal growth factor receptor 2 (HER2) and estrogen-receptor (ER) testing on core biopsy and excision specimens has been reported. [6] Adequate fixation appears to be a more important factor than biologic tumor heterogeneity. HER2 and ER testing is preferably performed on core biopsy specimens in the authors’ practice, because it is easier to standardize fixation times for core biopsy specimens and because test results are available at an earlier step in the management of the patient.


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