What are the limitations of core biopsy in the histologic grading of breast tumors?

Updated: Mar 20, 2019
  • Author: Oudai Hassan, MD; Chief Editor: Chandandeep Nagi, MD  more...
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Due to tumor heterogeneity, assessment of tubule formation and mitotic count on core biopsy may not be representative of the entire tumor. When more than the nuclear grade is reported on the core biopsy, a possible change in grade on the excision specimen should be expected.

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