What is the physiology of albumin damage in severe end-stage hepatic cirrhosis?

Updated: Sep 11, 2020
  • Author: Ruben Peralta, MD, FACS; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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Answer

Albumin has four binding sites, one for cobalt (metallic) and the others are for binding to various biologic and foreign molecular species. Albumin can be oxidized in a reversible fashion restored via the glutathione pathway, but in severe end-stage hepatic cirrhosis, it forms a nonreversible oxidized form that has markedly reduced molecular binding capabilities.


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