What is the role of antibiotics in the treatment of autoimmune lymphoproliferative syndrome (ALPS)?

Updated: Jul 29, 2019
  • Author: Akaluck Thatayatikom, MD, RhMSUS; Chief Editor: Harumi Jyonouchi, MD  more...
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Answer

All ALPS patients who are asplenic should be treated with long-term antibiotic (e.g., penicillin V) prophylaxis against pneumococcal sepsis. These patients are often unable to produce or maintain protective antibodies against polysaccharide antigens after vaccination because of deficient memory B-cell function. Nevertheless, they should be vaccinated against encapsulated organisms such as pneumococcus, meningococcus, and Haemophilus influenzae type B (HIB) and should wear an appropriate alert bracelet citing their increased risk of infection.


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