Which cytogenetic findings are characteristic of true malignant mixed tumor (carcinosarcoma)?

Updated: Dec 01, 2015
  • Author: M Sherif Said, MD, PhD; Chief Editor: M Sherif Said, MD, PhD  more...
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Answer

Answer

Few genetic studies have been performed on these tumors, owing to their rarity. However, abnormalities in chromosomes 7, 8, 9, 10, 12, 13, 17, and 18 have been described. [19, 20] A study showed specific amplifications of mucin 20 (MUC 20) in mesenchymal elements (gene products that are known to be overexpressed in various cancers and that correlate with poor outcome). BMI-1 (a proto-oncogene found to be deregulated in several neoplasms, including salivary gland tumors) was observed in both element loci. [19]


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