What is the role of benzodiazepines in the treatment of delirium tremens (DTs)?

Updated: Nov 06, 2020
  • Author: Michael James Burns, MD, FACEP, FACP, FIDSA; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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Answer

As mentioned previously, in critically ill patients in ICUs, symptom-triggered benzodiazepine treatment titrated to the RSAS or RASS, using very-high-dose bolus therapy, with addition of phenobarbital as needed, has been associated with a reduction in the need for mechanical ventilation and possibly a reduced length in the ICU. Fixed-dose regimens often result in excessive sedation or failure to reach the sedation goal.


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