What is the role of lower-volume trophic enteral feeding in the treatment of acute respiratory distress syndrome (ARDS)?

Updated: Mar 27, 2020
  • Author: Eloise M Harman, MD; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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Answer

An open-label, multicenter trial (the EDEN study) randomized 1000 adult patients who required mechanical ventilation within 48 hours of developing acute lung injury to receive either trophic or full enteral feeding for the first 6 days. Initial lower-volume trophic enteral feeding did not improve ventilator-free days, 60-day mortality, or infectious complications compared with initial full enteral feeding, but it was associated with less gastrointestinal intolerance. [57]


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