What are the disadvantages to mechanical ventilation in the treatment of acute respiratory distress syndrome (ARDS)?

Updated: Mar 27, 2020
  • Author: Eloise M Harman, MD; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, FAPS, MCCM  more...
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Answer

A study by Jaber et al examined diaphragmatic weakness during mechanical ventilation along with the relationship between mechanical ventilation duration and diaphragmatic injury or atrophy. [41] The study determined that longer periods of mechanical ventilation were associated with significantly greater ultrastructural fiber injury, increased ubiquitinated proteins, higher expression of p65 nuclear factor-kB, greater levels of calcium-activated proteases, and decreased cross-sectional area of muscle fibers in the diaphragm. The conclusion was that weakness, injury, and atrophy can occur rapidly in the diaphragms of patients on mechanical ventilation and are significantly correlated with the duration of ventilator support.

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