How is hyperglycemia treated in metabolic syndrome?

Updated: Mar 30, 2020
  • Author: Stanley S Wang, JD, MD, MPH; Chief Editor: Yasmine S Ali, MD, MSCI, FACC, FACP  more...
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Drug therapy for hyperglycemia in patients with metabolic syndrome typically begins with an insulin-sensitizing agent, such as metformin. Some literature suggests that metformin may help to reverse the pathophysiologic changes of metabolic syndrome. This includes when it is used in combination with lifestyle changes [102] or with peroxisome proliferator-activated receptor agonists, such as the fibrates [103] and thiazolidinediones (eg, pioglitazone, rosiglitazone), [104, 105] each of which may produce favorable metabolic alterations as single agents in patients with metabolic syndrome. [106]

Management of diabetes mellitus, including screening for end-organ complications, should proceed under current guidelines. [107]

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