According to the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, what does acute myeloid leukemia (AML) with myelodysplasia-related changes (AML-MRC) encompass?

Updated: Feb 25, 2018
  • Author: Angie Duong, MD; Chief Editor: Christine G Roth, MD  more...
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Answer

Answer

The 2016 update to the World Health Organization (WHO) Classification of Tumours of Haematopoietic and Lymphoid Tissues has focused increased attention on genetic abnormalities to characterize and subclassify AML, including AML-MRC. [1]

AML-MRC encompasses:

  • AML arising in MDS or in MDS/MPN
  • AML with MDS-related cytogenetic abnormalities
  • AML with multilineage dysplasia

This category of AML primarily occurs in elderly patients; it is rare in children. AML-MRC represents 25%-35% of AML cases. [2, 3, 4, 5]


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