What are the diagnostic criteria for acute myeloid leukemia (AML) with myelodysplasia-related changes (AML-MRC)?

Updated: Jul 28, 2020
  • Author: Angie Duong, MD; Chief Editor: Aliyah R Sohani, MD  more...
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Answer

Answer

Acute myeloid leukemia (AML) with myelodysplasia-related changes (AML-MRC) includes those forms of AML that occur in patients with any of the following criteria:

  • A previous history of a myelodysplastic syndrome (MDS) or a myelodysplastic/myeloproliferative neoplasm (MDS/MPN)
  • An MDS-related cytogenetic abnormality
  • Multilineage dysplasia in at least 50% of cells of at least two cell lineages, in the absence of  NPM1 or biallelic  CEBPA mutations

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