Which medications in the drug class Antiarrhythmic Drugs are used in the treatment of Brugada Syndrome?

Updated: Apr 03, 2020
  • Author: Jose M Dizon, MD; Chief Editor: Mikhael F El-Chami, MD  more...
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Antiarrhythmic Drugs

There is general consensus that certain drugs can be potentially antiarrhythmic in Brugada syndrome patients. However, there are no randomized clinical studies in Brugada syndrome patients. As such, only in the setting of long-term therapeutic treatment in an experienced medical center can practitioners consider the use of antiarrhythmics for high-risk patients. Currently, quinidine seems to be the treatment of choice for long-term therapy.


Quinidine maintains a normal heart rhythm following cardioversion of atrial fibrillation or flutter. It depresses myocardial excitability and conduction velocity. Prior to administration, control the ventricular rate and CHF (if present) with digoxin or calcium channel blockers.

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