What were the results of the AMIOVIRT study of cardioverter-defibrillator (ICD) therapy?

Updated: Oct 11, 2019
  • Author: Daniel M Beyerbach, MD, PhD; Chief Editor: Jeffrey N Rottman, MD  more...
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A small trial that directly compared ICD therapy with medical therapy of amiodarone found no mortality difference between the 2 treatments at 3 years. The Amiodarone Versus Implantable Cardioverter-Defibrillator Randomized Trial (AMIOVIRT) studied 103 subjects with nonischemic cardiomyopathy and was stopped early when a prespecified rule for futility was reached. [29] (The SCD-HeFT trial provided only an indirect comparison between amiodarone therapy and ICD therapy because the trial was designed only to compare each of these therapies individually with optimal medical therapy.) [21]

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