What were the results of the CABG-Patch trial of implantable cardioverter-defibrillator (ICD) therapy?

Updated: Feb 13, 2017
  • Author: Daniel M Beyerbach, MD, PhD; Chief Editor: Jeffrey N Rottman, MD  more...
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Answer

Answer

In the Coronary Artery Bypass Graft (CABG)-Patch trial, ICD implantation improved the sudden cardiac death mortality rate but not the total mortality rate. In the study, subjects undergoing CABG who had decreased left ventricular function (ejection fraction < 35%) and an abnormal signal-averaged electrocardiogram (SAECG) were randomized to epicardial ICD implantation at the time of CABG or to a control group. [27] The lack of effectiveness of IDCs on the mortality rate apparently resulted from the poor predictive value of a preoperative SAECG in identifying patients at risk for arrhythmic death or the salutatory effects of coronary revascularization in reducing the risk of arrhythmic death.


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