Which trials have shown no benefit from implantable cardioverter-defibrillator (ICD) therapy?

Updated: Oct 11, 2019
  • Author: Daniel M Beyerbach, MD, PhD; Chief Editor: Jeffrey N Rottman, MD  more...
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At least four notable, published implantable cardioverter-defibrillator (ICD) trials have failed to demonstrate a significant survival benefit to ICD therapy over optimal medical therapy. Two of these trials examined patients with ischemic cardiomyopathy and two examined patients with nonischemic cardiomyopathy.

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