What were the results of the MADIT study of implantable cardioverter-defibrillator (ICD) therapy?

Updated: Feb 13, 2017
  • Author: Daniel M Beyerbach, MD, PhD; Chief Editor: Jeffrey N Rottman, MD  more...
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Answer

Answer

Similar to the AVID trial, MADIT was terminated prematurely because of a significant survival benefit seen in patients treated with ICDs. MADIT in 1996 had enrolled patients with ischemic cardiomyopathy (LVEF ≤35%) and asymptomatic, nonsustained VT who had inducible sustained VT or VF not suppressible with procainamide infusion during electrophysiology study (EPS). Enrolled patients were randomized to either ICD implantation or to therapy considered appropriate by the treating physician. Antiarrhythmic drug therapy was administered in both arms as considered appropriate by the treating physician. [14]


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