What is included in antiplatelet therapy for percutaneous coronary intervention (PCI)?

Updated: Nov 27, 2019
  • Author: George A Stouffer, III, MD; Chief Editor: Karlheinz Peter, MD, PhD  more...
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Patients receiving stents are treated with a combination of aspirin and a P2Y12 receptor inhibitor (clopidogrel, prasugrel, or ticagrelor). The minimum duration of P2Y12 receptor inhibitor therapy, as per the current ACCF/AHA guidelines, is as follows:

  • BMSs - Minimum of 4 weeks
  • DESs (for acute coronary syndrome patients) - Minimum of 12 months
  • DESs (for stable ischemic heart disease patients) - Minimum of 6 months
  • DESs (for patients who are at high risk for bleeding) - Minimum of 3 months may be reasonable

Use of proton pump inhibitors (PPIs) is appropriate in patients with multiple risk factors for gastrointestinal bleeding who require antiplatelet therapy.

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