What is the gross description of sarcomatoid renal cell carcinoma (SRCC)?

Updated: Mar 11, 2019
  • Author: Ronald J Cohen, MB, BCh, PhD, FRCPA, FFPATH; Chief Editor: Liang Cheng, MD  more...
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Answer

Answer

On gross inspection, the sarcomatoid components of SRCC appear as solid gray/white areas with an invasive margin and a firm, fleshy-to-fibrous cut surface. (See the image below.) Regions of hemorrhage and necrosis are common. [7, 17, 18] Tumor sizes in published series of SRCC range from 3-25 cm, with mean diameters of 9.2-11 cm. [3, 7, 30]

Sarcomatoid renal cell carcinoma arising from a cl Sarcomatoid renal cell carcinoma arising from a clear cell renal cell carcinoma (lower left). Clear cell areas are golden in color due to cellular lipid accumulation while sarcomatoid foci are white. Note tumor extension along the renal vein.

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