What is the prevalence of sarcomatoid renal cell carcinoma (SRCC)?

Updated: Mar 11, 2019
  • Author: Ronald J Cohen, MB, BCh, PhD, FRCPA, FFPATH; Chief Editor: Liang Cheng, MD  more...
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Answer

Answer

Sarcomatoid differentiation is reported in 4-32% of RCCs overall. [2, 4, 6, 7] The incidence rates according to RCC histologic subtypes are 5-13% for clear cell renal cell carcinoma (CCRCC), 2-7% for papillary RCC, 9-13% for chromophobe RCC, and 11-26% for unclassified RCC. Sarcomatoid differentiation also occurs in around 29% of carcinomas of the collecting duct of Bellini. [4, 7, 15, 16]

Histologic sources of origin for SRCC, by percentage, are as follows [4, 7] :

  • CCRCC, 79-87%

  • Chromophobe RCC, 7-7.5%

  • Papillary RCC, 4-8%

  • Unclassified RCC, 2-4%

  • Collecting (Bellini) duct carcinoma, 2%

The average age at diagnosis of SRCC is 56-61 years, with male-to-female ratios ranging between 1.6:1 and 2.2:1. [3, 4, 7]


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