What is the histologic definition of adult rhabdoid renal cell carcinoma (RRCC)?

Updated: Mar 11, 2019
  • Author: Ronald J Cohen, MB, BCh, PhD, FRCPA, FFPATH; Chief Editor: Liang Cheng, MD  more...
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Answer

Answer

Adult rhabdoid renal cell carcinoma (RRCC) is currently recognized in the literature as any histologic type of RCC containing foci of high-grade malignant cells with rhabdoid morphology, characterized by large eccentric vesicular nuclei, prominent nucleoli, globular eosinophilic paranuclear inclusion bodies, and abundant eosinophilic cytoplasm. [8, 9, 10, 11]

The proportion of rhabdoid components in published series of RRCC ranges from 1-90% of the total tumor volume [8, 10, 11] ; however, occasional tumors composed entirely of rhabdoid cells have been described in which no RCC component is detected despite extensive sampling. [9, 12]


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